Research

🧬 Metabolic Engineering

Enhancing chemical synthesis efficiency

We use metabolic engineering and laboratory adaptive evolution to enhance the efficiency of bulk chemical synthesis in non-model microorganisms. Our approach follows the Design-Build-Test-Learn (DBTL) cycle to continuously improve production strains.

• Pathway optimization and balancing
• Strain adaptation and evolution
• Bioreactor scale-up

🔬 Multi-omics Analysis

Understanding metabolic mechanisms

We apply multi-omics approaches (genomics, transcriptomics, proteomics, metabolomics) to understand metabolic mechanisms in non-model microorganisms and achieve optimal synthetic pathways.

• Metabolic pathway analysis
• Regulatory network mapping
• System-level modeling

✂️ Genome Editing Tools

Novel tools for precision engineering

We investigate transposase-mediated genome rearrangement during adaptive laboratory evolution and develop novel genome editing tools based on these insights.

• Transposon-based tools
• CRISPR-Cas systems
• Genome rearrangement studies