2026
ISPpu10 is a structure-gated bridge RNA recombinase that drives safe, large-scale genomic plasticity
Xue-Mei Na#, Bai-Tao Chen#, Han Liu#, Yi-Tong Lin, Yuan Yuan, Tai-Jiang Chen, Yi-Na Xiong, Yu-Hang Zhang, Nan Yang, Fei Zhu, Yingying Zhang, Ximin Chi, Zhiyou Zong*, Chen Ling*
bioRxiv, 2026. doi: 10.64898/2026.03.19.712850
2025
Comparing three emerging industrial cell factories: Pseudomonas putida KT2440, Halomonas bluephagenesis TD01, and Zymomonas mobilis ZM4
Yu-Hang Zhang, Chen-Ming Xue, Bai-Tao Chen, Pengfei Ouyang*, Chen Ling*
Current Opinion in Biotechnology, Volume 92, April 2025, 103255. (Review)
Tunable and degradable dynamic thermosets from compatibilized polyhydroxyalkanoate blends
Chen Ling#, Ryan W. Clarke#, Gloria Rosetto#, Shu Xu, Robin M. Cywar, Dong Hyun Kim, Levi J. Hamernik, Stefan J. Haugen, William E. Michener, Sean P. Woodworth, Torrey M. Lind, Kelsey J. Ramirez, Meltem Urgun-Demirtas, Davinia Salvachúa, Christopher W. Johnson, Nicholas A. Rorrer*, Gregg T. Beckham*
ACS Sustainable Chemistry & Engineering, 2025, 13(9), 3817-3829. Published February 27, 2025. (Research Article)
2023
Biodegradable and reprocessable thermosets from microbially-produced unsaturated polyhydroxyalkanoates
Robin M. Cywar#, Chen Ling#, Ryan W. Clarke, Donghyun Kim, Colin Kneucker, Davinia Salvachúa, Shu Xu, Meltem Urgun Demirtas, Bennett Addison, Nicholas Rorrer, Christopher W. Johnson, Robert Allen, Eugene Y.-X. Chen, Gregg T. Beckham*
Science Advances, 2023. 9(47), eadi1735.
2022
Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering
Chen Ling, George L. Peabody, Davinia Salvachúa, Young-Mo Kim, Colin M. Kneucker, Christopher H. Calvey, Michela A. Monninger, Nathalie Munoz Munoz, Brenton C. Poirier, Kelsey J. Ramirez, Peter C. St. John, Sean P. Woodworth, Jon K. Magnuson, Kristin E. Burnum-Johnson, Adam M. Guss, Christopher W. Johnson & Gregg T. Beckham
Nature Communications, 2022, 13, 4921.
2019
Engineering self-flocculating Halomonas campaniensis for wastewaterless open and continuous fermentation
Chen Ling#, Guan-Qing Qiao#, Bo-Wen Shuai#, Kun-Nan Song, Wen-Xi Yao, Xiao-Ran Jiang*, Guo-Qiang Chen*
Biotechnology and Bioengineering, 2019, 116(4): 805-815.
Microbial engineering for easy downstream processing
Ying Wang, Chen Ling, Yong Chen, Xiao-Ran Jiang, Guo-Qiang Chen*
Biotechnology Advances, 2019. 37(6): 107365.
2018
CRISPR/Cas9 editing genome of extremophile Halomonas spp
Qin Qin, Chen Ling, Yiqing Zhao, Tian Yang, Jin Yin, Yingying Guo*, Guo-Qiang Chen*
Metabolic Engineering, 2018, 47: 219-229.
Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA)
Chen Ling, Guan-Qing Qiao, Bo-Wen Shuai, Karel Olavarria, Jin Yin, Rui-Juan Xiang, Kun-Nan Song, Yun-Hao Shen, Yingying Guo*, Guo-Qiang Chen*
Metabolic Engineering, 2018, 49: 275-286.
Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production
Yilin Ren, Chen Ling, Ivan Hajnal, Qiong Wu, Guo-Qiang Chen*
Applied Microbiology and Biotechnology, 2018. 102(10): 4499-4510.
2014
A seawater-based open and continuous process for polyhydroxyalkanoates production by recombinant Halomonas campaniensis LS21 grown in mixed substrates
Haitao Yue, Chen Ling, Tao Yang, Xiangbin Chen, Yuling Chen, Haiteng Deng, Qiong Wu, Jinchun Chen & Guo-Qiang Chen*
Biotechnology for Biofuels, 2014. 7(1): 108.